Age-Related Eye Disease Study 2 or AREDS II is a study of how nutrients can affect the eyesight. The first study, conducted in 2001, had shown that a high level of antioxidants could reduce the risk of blindness up to 25 percent. However, there were problems with the formulation and the second study effectively addressed these issues.

People with eye disease have said that it is very debilitating. This affects nearly a million people, around 90% elderly, in the United States. People can develop eye disease in several ways. Some are born blind because of defects during the pregnancy. Others go blind after injury or due to diabetes complications. The majority of people that are blind have suffered cataracts or age-related macular degeneration (AMD), which is an aging disease.

Most treatments that exist today are only good for a limited range of eye diseases and have limited efficacy. One of the most common currently available treatments is laser surgery; while it has been shown to reduce the risks of blindness, the surgery is very costly and could even result in complications. Although not usually severe, the side effects are quite common; some of these include loss of peripheral vision, reduced night vision, worsening visual acuity, and even hemorrhaging.

AREDS, the initial Age-Related Eye Disease Study was finished and released in 2001. This study was begun to review risk factors and history associated with cataracts and AMD. Another purpose was to analyze whether higher doses of antioxidants might affect AMD or cataracts. They looked at a combination of vitamin C, vitamin E, zinc, and beta-carotene.

The research team found that antioxidants in high doses could lessen the chance of blindness. For high risk individuals, such as those with AMD in one of their eyes or intermediate in both, it brought down the risk nearly 25 percent. One of the ingredients in the initial combination was beta-carotene. Later studies showed that beta-carotene increased the possibility of lung cancer in smokers. They also discovered that it had no effect on the incidence of cataracts.

The next study was finished in May 2013 and had some interesting results. One goal that they had was to discern whether an adequate substitute existed for the beta-carotene. They tried lutein and zeaxanthin and found that they were as effective as the beta-carotene. For people at high risk of advanced AMD this is an important consideration and could help lessen the possibility of developing blindness.

Many older persons are on prescription medications. Also, they use many over-the-counter drugs and dietary supplements. High-dose supplemental nutrients could interfere with some of these medications and keep other vital nutrients from properly absorbing.

Laser surgery has definite benefits but is expensive and can cause serious complications. An alternative may be the combination formulated by the researchers in the AREDS II study. They found that high levels of antioxidants, combined with vitamins and zinc, reduced AMD risk. They also discovered that zeaxanthin and lutein were adequate substitutes for beta-carotene, while not reducing the beneficial properties. Before you start any new medicines you should consult your physician.