As medical remedies have aggressively gone through the heights, several scientific developments have has been initiated so as to strike a balance on the skyrocketing costs of treatments. One of the most impressive breakthrough so far has been the clodronate liposome. This liposome is a synthetic lipid vesicle that has high concentration for lipid bilayers. This has been used in encapsulating hydrophilic molecule which is particularly important in pharmaceutical drug preparations for human application.

Liposomes have natural phospholipids, as well as mixed lipid chains of surfactant elements. These are specifically designed to surface ligands in attaching unhealthy tissues. They can be prepared through having the biological membranes like the bysonication disrupted. They consist of three primary types; the multilamellar vesicle or MLV, small unilamellar vesicle or SUV and large unilamellar vesicle or LUV. All three have specific tasks which are not to be confused with the reverse micelles or inverse micelles, non-solvents which are used as emulsifiers when surfactants are found before the critical micelle concentration or CMC.

Liposomes were discovered by accident in 1961 when a certain group of researchers were working on a then critical test for a new electron microscope at the Babraham Institute. These became pretty apparent as they tried to add negative strain in the dry phospholipids. Vivid resemblance of plasmalemma was noted that was proven through several microscopic pictures taken for the cell membranes.

Liposome was coined up in conjunction with the high composition of phospholipids found within the it. Lipo means fat in Greek while soma means body. It can shut in specific region of aqueous solutions within the hydrophilic membranes which break up in the hydrophilic solute disabling such solutions to pass through lipid membranes.

With hydrophobic chemicals beginning to dissolve into the membranes, it is easier for these liposomes to carry hydrophobic and hydrophilic particles. These molecules are delivered straight to sites wherein lipid bilayers can easily fuse with the membranes. The liposomes, however, have no significant amounts of lipohobic agent like water.

Liposomes with low pH are designed to dissolve aqueous drugs. It is no wonder these are used in delivering drugs in several ways. With the pH neutralizing naturally in the protons of the liposome, drugs can also be neutralized.

Liposomes are in various sizes making these entirely viable targets on a macrophage phagocytosis. These can be processed in the phagosome of macrophage. They can likewise be made through having the endocytosis activated with the use of specific ligands.

Today, several approved drugs have already been used widely in the medical practice. New liposomal drugs are designed to annihilate cancer cells. These, however, are still under a series of clinical trials. Hence, it is never ideal to take in without the doctors' prescriptions. Over-the-counter medications can never be practical especially on serious medical complications.

Moreover, clodronate liposome is employed not simply in medical context. It is also utilized greatly in productions of nutritional supplements, textiles and cosmetics. Its huge role in nanotechnology eminently enables researchers to discover much more acceptable application in today's scientific activities.